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Table 3 Etiology of CN Model Proposed by Koeck et al

From: Charcot stage 0: A review and consideratons for making the correct diagnosis early

 

Skin (OA)

Skin (CN)

Synovium (OA)

Synovium (CN)

Bone (OA)

Bone (CN)

Substance P positive Nerve Fibers

~3.5 nerve fiber per mm2

~3 nerve fiber per mm2

~3 nerve fiber per mm2

~2 nerve fiber per mm2

~4.5 nerve fiber per mm2

~4 nerve fiber per mm2

Sympathetic Nerve Fibers

~7 nerve fiber per mm2

~2 nerve fiber per mm2

~3 nerve fiber per mm2

~0.5 nerve fiber per mm2

~1.5 nerve fiber per mm2

~0.25 nerve fiber per mm2

  1. Density of Substance P Nerve Fibers and Sympathetic Nerve Fibers in Skin, Synovium, and Bone of Patient’s with Charcot Neuroarthropathy and Osteoarthritis
  2. Table is adapted from Koeck et al [56]. In their study they demonstrated that the Charcot joint (synovium) demonstrates a lack of sympathetic control compared to the control sample of patients with osteoarthritic joints. Here we report the approximate mean from their study to demonstrate the difference. The p-value between synovium concentration of sympathetic nerve fibers is <0.006 and indicates a significant difference between the two conditions. It was the only difference between the two groups that was significant
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Clinical Diabetes and Endocrinology

ISSN: 2055-8260

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