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Table 8 Levels of Evidence (Miline) [50]

From: Charcot stage 0: A review and consideratons for making the correct diagnosis early

Level of Evidence

Definition

I

A systematic review of level II studies

II

A randomized controlled trial

III

A pseudorandomized controlled trial (alternate allocation, etc.)

III-2

A comparative study with concurrent controls (cohort, case–control)

III-3

A comparative study without concurrent control (historical cohort)

IV

Case Series

EO

Expert Opinion – where evidence was absent or unreliable and advice was formulated based on clinical judgement of experts in the fields