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Table 3 Etiology of CN Model Proposed by Koeck et al

From: Charcot stage 0: A review and consideratons for making the correct diagnosis early

  Skin (OA) Skin (CN) Synovium (OA) Synovium (CN) Bone (OA) Bone (CN)
Substance P positive Nerve Fibers ~3.5 nerve fiber per mm2 ~3 nerve fiber per mm2 ~3 nerve fiber per mm2 ~2 nerve fiber per mm2 ~4.5 nerve fiber per mm2 ~4 nerve fiber per mm2
Sympathetic Nerve Fibers ~7 nerve fiber per mm2 ~2 nerve fiber per mm2 ~3 nerve fiber per mm2 ~0.5 nerve fiber per mm2 ~1.5 nerve fiber per mm2 ~0.25 nerve fiber per mm2
  1. Density of Substance P Nerve Fibers and Sympathetic Nerve Fibers in Skin, Synovium, and Bone of Patient’s with Charcot Neuroarthropathy and Osteoarthritis
  2. Table is adapted from Koeck et al [56]. In their study they demonstrated that the Charcot joint (synovium) demonstrates a lack of sympathetic control compared to the control sample of patients with osteoarthritic joints. Here we report the approximate mean from their study to demonstrate the difference. The p-value between synovium concentration of sympathetic nerve fibers is <0.006 and indicates a significant difference between the two conditions. It was the only difference between the two groups that was significant