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Table 8 Levels of Evidence (Miline) [50]

From: Charcot stage 0: A review and consideratons for making the correct diagnosis early

Level of Evidence Definition
I A systematic review of level II studies
II A randomized controlled trial
III A pseudorandomized controlled trial (alternate allocation, etc.)
III-2 A comparative study with concurrent controls (cohort, case–control)
III-3 A comparative study without concurrent control (historical cohort)
IV Case Series
EO Expert Opinion – where evidence was absent or unreliable and advice was formulated based on clinical judgement of experts in the fields