Skip to main content

Table 1 Association of diabetes mellitus and fracture risk

From: Diabetes mellitus and bone health: epidemiology, etiology and implications for fracture risk stratification

Type of diabetes Fracture type Findings Study design Reference
Type 1 diabetes mellitus Hip fracture RR 7.10 (CI 95%: 4.4–11.4) Prospective observational Janghorbani et al.
Type 1 diabetes mellitus Men 60-69yo Any type HR 2.00 (CI 95%: 1.63–2.45) Prospective observational Weber et al.
Hip fracture HR 5.21 (CI 95%: 3.2–8.47)
Type 1 diabetes mellitus Men 40-49yo Any type HR 1.82 (CI 95%: 1.53–11.43)
Type 1 diabetes mellitus Men 30-39yo Hip fracture HR 4.16 (CI 95%: 1.52–11.43)
Type 1 diabetes mellitus Vertebral fracture OR 4.20 (CI 95%: 1.40–12.7) Cross sectional Zhukouskaya et al.
Type 1 diabetes mellitus men Hip fracture HR 1.28 (CI 95%: 1.21–1.34) Prospective observational Chen et al.
Type 1 diabetes mellitus women Hip fracture HR 1.72 (CI 95%: 1.66–1.78)
Type 1 diabetes mellitus Hip fracture RR 6.94 (CI 95%: 3.25–14.78) Meta-analysis observational studies Vastergaard et al.
Type 2 diabetes mellitus Hip fracture RR 1.38 (CI 95%: 1.25–1.53)
Type 2 diabetes mellitus Any site RR 1.20 (CI 95%: 1.11–1.30) Prospective observational Bonds et al.
Type 2 diabetes mellitus Non-vertebral RR 1.30 (CI 95%: 1.10–1.53) Prospective observational Schwartz et al.
Hip fracture RR 1.82 (CI 95%: 1.24–2.69)
Vertebral RR 1.12 (CI 95%: 0.69–1.83)
Type 2 diabetes mellitus Men Vertebral OR 4.73 (CI 95% 2.19–10.20) Cross sectional Yamamoto et al.
Type 2 diabetes mellitus Women Vertebral OR 1.86 (CI 95% 1.11–3.12)
Type 2 diabetes mellitus Men Vertebral OR 0.77 (CI 95% 0.48–1.22) Cross sectional Hanley et al.
Type 2 diabetes mellitus Women Vertebral OR 0.92 (CI 95% 0.67–1.26)
  1. Findings in bold letters indicate a significant positive association
  2. RR: relative risk; HR: hazard ratio; OR: odds ratio