Table 1 Association of diabetes mellitus and fracture risk
Type of diabetes | Fracture type | Findings | Study design | Reference |
|---|---|---|---|---|
Type 1 diabetes mellitus | Hip fracture | RR 7.10 (CI 95%: 4.4–11.4) | Prospective observational | Janghorbani et al. |
Type 1 diabetes mellitus Men 60-69yo | Any type | HR 2.00 (CI 95%: 1.63–2.45) | Prospective observational | Weber et al. |
Hip fracture | HR 5.21 (CI 95%: 3.2–8.47) | |||
Type 1 diabetes mellitus Men 40-49yo | Any type | HR 1.82 (CI 95%: 1.53–11.43) | ||
Type 1 diabetes mellitus Men 30-39yo | Hip fracture | HR 4.16 (CI 95%: 1.52–11.43) | ||
Type 1 diabetes mellitus | Vertebral fracture | OR 4.20 (CI 95%: 1.40–12.7) | Cross sectional | Zhukouskaya et al. |
Type 1 diabetes mellitus men | Hip fracture | HR 1.28 (CI 95%: 1.21–1.34) | Prospective observational | Chen et al. |
Type 1 diabetes mellitus women | Hip fracture | HR 1.72 (CI 95%: 1.66–1.78) | ||
Type 1 diabetes mellitus | Hip fracture | RR 6.94 (CI 95%: 3.25–14.78) | Meta-analysis observational studies | Vastergaard et al. |
Type 2 diabetes mellitus | Hip fracture | RR 1.38 (CI 95%: 1.25–1.53) | ||
Type 2 diabetes mellitus | Any site | RR 1.20 (CI 95%: 1.11–1.30) | Prospective observational | Bonds et al. |
Type 2 diabetes mellitus | Non-vertebral | RR 1.30 (CI 95%: 1.10–1.53) | Prospective observational | Schwartz et al. |
Hip fracture | RR 1.82 (CI 95%: 1.24–2.69) | |||
Vertebral | RR 1.12 (CI 95%: 0.69–1.83) | |||
Type 2 diabetes mellitus Men | Vertebral | OR 4.73 (CI 95% 2.19–10.20) | Cross sectional | Yamamoto et al. |
Type 2 diabetes mellitus Women | Vertebral | OR 1.86 (CI 95% 1.11–3.12) | ||
Type 2 diabetes mellitus Men | Vertebral | OR 0.77 (CI 95% 0.48–1.22) | Cross sectional | Hanley et al. |
Type 2 diabetes mellitus Women | Vertebral | OR 0.92 (CI 95% 0.67–1.26) |