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Table 1 Time course of laboratory parameters during outpatient care and on arrival

From: Isolated ACTH deficiency during single-agent pembrolizumab for squamous cell lung carcinoma: a case report

 

Before administration

2nd cycle

4th cycle

5th cycle

7th cycle

8th cycle

On arrival

  

White blood cell count

5700

6200

6000

5600

5500

6600

6100

/μL

(3300-8600)

Neutrophil

55.7

54.8

63.3

57.9

59.0

59.2

60.2

%

(40–70)

Eosinophil

3.8

4.3

4.8

4.9

3.5

3.1

3.7

%

(0–5)

Sodium

143

142

139

143

142

139

122

mmol/L

(138–145)

Glucose

107

116

99

100

90

102

68

mg/dL

(73–109)

Cortisol

6.67

5.42

8.66

6.23

9.98

7.16

0.92

μg/dL

(6.24–18.0)

ACTH

19.0

NA

NA

NA

NA

NA

8.3

pg/mL

(7.2–63.3)

DHEA-S

NA

NA

NA

NA

NA

NA

5

μg/dL

(7–177)

TSH

2.05

2.13

2.00

2.37

2.45

2.15

3.39

μIU/mL

(0.34–3.8)

FT3

2.77

2.27

2.13

2.1

2.21

2.14

2.65

pg/mL

(2.0–3.8)

FT4

0.83

1.02

0.93

0.84

0.81

0.83

0.86

ng/dL

(0.8–1.5)

Prolactin

NA

NA

NA

NA

NA

NA

18.3

ng/mL

(4.1–28.9)

LH

NA

NA

NA

NA

NA

NA

15.0

mIU/mL

(5.72–64.31)

FSH

NA

NA

NA

NA

NA

NA

50.9

mIU/mL

(< 157.79)

Estradiol

NA

NA

NA

NA

NA

NA

9.3

pg/mL

(< 47.0)

Progesterone

NA

NA

NA

NA

NA

NA

< 0.05

ng/mL

(< 0.33)

GH

NA

NA

NA

NA

NA

NA

3.83

ng/mL

(0.13–9.88)

IGF-1

NA

NA

NA

NA

NA

NA

78

ng/mL

 

ADH

NA

NA

NA

NA

NA

NA

3.1

pg/mL

(< 2.8)

  1. Laboratory parameters were obtained before breakfast on the morning before starting administration, and before the second, fourth, fifth, seventh, and eighth cycle of pembrolizmab infusion. Parameters measured on arrival of 1300 h are also shown. Available reference ranges for 85 year-old postmenopausal Japanese women are shown in parentheses. ACTH adrenocorticotropic hormone; ADH antidiuretic hormone; DHEA-S dehydroepiandrosterone sulfate; FSH follicle stimulating hormone; FT3 free triiodothyronine; FT4 free thyroxine; GH growth hormone; IGF1 insulin-like growth factor 1; LH luteinizing hormone; NA not applicable; TSH thyroid stimulating hormone