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Table 1 Time course of laboratory parameters during outpatient care and on arrival

From: Isolated ACTH deficiency during single-agent pembrolizumab for squamous cell lung carcinoma: a case report

 Before administration2nd cycle4th cycle5th cycle7th cycle8th cycleOn arrival  
White blood cell count5700620060005600550066006100/μL(3300-8600)
Neutrophil55.754.863.357.959.059.260.2%(40–70)
Eosinophil3.84.34.84.93.53.13.7%(0–5)
Sodium143142139143142139122mmol/L(138–145)
Glucose107116991009010268mg/dL(73–109)
Cortisol6.675.428.666.239.987.160.92μg/dL(6.24–18.0)
ACTH19.0NANANANANA8.3pg/mL(7.2–63.3)
DHEA-SNANANANANANA5μg/dL(7–177)
TSH2.052.132.002.372.452.153.39μIU/mL(0.34–3.8)
FT32.772.272.132.12.212.142.65pg/mL(2.0–3.8)
FT40.831.020.930.840.810.830.86ng/dL(0.8–1.5)
ProlactinNANANANANANA18.3ng/mL(4.1–28.9)
LHNANANANANANA15.0mIU/mL(5.72–64.31)
FSHNANANANANANA50.9mIU/mL(< 157.79)
EstradiolNANANANANANA9.3pg/mL(< 47.0)
ProgesteroneNANANANANANA< 0.05ng/mL(< 0.33)
GHNANANANANANA3.83ng/mL(0.13–9.88)
IGF-1NANANANANANA78ng/mL 
ADHNANANANANANA3.1pg/mL(< 2.8)
  1. Laboratory parameters were obtained before breakfast on the morning before starting administration, and before the second, fourth, fifth, seventh, and eighth cycle of pembrolizmab infusion. Parameters measured on arrival of 1300 h are also shown. Available reference ranges for 85 year-old postmenopausal Japanese women are shown in parentheses. ACTH adrenocorticotropic hormone; ADH antidiuretic hormone; DHEA-S dehydroepiandrosterone sulfate; FSH follicle stimulating hormone; FT3 free triiodothyronine; FT4 free thyroxine; GH growth hormone; IGF1 insulin-like growth factor 1; LH luteinizing hormone; NA not applicable; TSH thyroid stimulating hormone