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Table 2 Previously reported cases of secondary adrenal insufficiency associated with pembrolizumab treatment

From: Isolated ACTH deficiency during single-agent pembrolizumab for squamous cell lung carcinoma: a case report

AgeSexDiseaseTherapeutic agentsOnsetDescription of pituitary imaging
60malelung cancerpembrolizumab
cisplatin
pemetrexed
15 months after stopping pembrolizumabno pituitary gland enlargement
55femalebreast cancerpembrolizumab
nab-paclitaxel
carboplatin
adriamycin
cyclophosphamide
6 months after stopping pembrolizumabno pituitary metastasis