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Table 2 Previously reported cases of secondary adrenal insufficiency associated with pembrolizumab treatment

From: Isolated ACTH deficiency during single-agent pembrolizumab for squamous cell lung carcinoma: a case report

Age

Sex

Disease

Therapeutic agents

Onset

Description of pituitary imaging

60

male

lung cancer

pembrolizumab

cisplatin

pemetrexed

15 months after stopping pembrolizumab

no pituitary gland enlargement

55

female

breast cancer

pembrolizumab

nab-paclitaxel

carboplatin

adriamycin

cyclophosphamide

6 months after stopping pembrolizumab

no pituitary metastasis