Table 4 Labs and Tumor Properties of Patients with Complete Initial Resection
Factor | Incomplete (N = 49) | Complete (N = 86) | ||||
|---|---|---|---|---|---|---|
n | n (%) or Median [P25, P75] | n | n (%) or Median [P25, P75] | p-value | Odds Ratios(95% CI) | |
Random GH level at Dx | 46 | 25.4[4.5,62.9] | 78 | 6.3[2.6,21.1] | 0.001b | 0.98 (0.97, 1.00) |
IGF-1 level at Dx | 49 | 784.0[675.0,1014.0] | 84 | 752.0[528.5944.0] | 0.30b | 1.00 (1.00, 1.00) |
2-h nadir post OGTT GH at Dx | 12 | 8.2[1.8,29.7] | 31 | 4.3[1.7,12.8] | 0.59b | 1.00 (0.99, 1.01) |
Most recent random GH level | 45 | 1.4[0.32,2.2] | 82 | 0.59[0.30,1.6] | 0.11b | 0.99 (0.96, 1.02) |
Most recent IGF-1 level | 49 | 217.0[153.0,377.0] | 84 | 205.5[161.0,272.5] | 0.50b | 1.00 (1.00, 1.00) |
Most recent 2-h nadir post OGTT GH | 9 | 0.51[0.21,1.3] | 23 | 0.30[0.16,0.80] | 0.35b | 0.74 (0.26, 2.1) |
Tumor size | 49 | 85 | 0.077c | |||
• Macroadenoma | 44(89.8) | 66(77.6) | reference | |||
• Microadenoma | 5(10.2) | 19(22.4) | 2.5 (0.88, 7.3) | |||
Tumor length/antero-posterior | 43 | 22.0[14.0,29.0] | 82 | 14.5[10.0,18.0] | < 0.001b | 0.92 (0.88, 0.96) |
Tumor width/transverse | 42 | 20.5[15.0,25.0] | 74 | 14.5[10.0,18.0] | < 0.001b | 0.89 (0.84, 0.94) |
Tumor height/craniocaudal | 39 | 20.0[15.0,25.0] | 66 | 13.0[9.0,16.0] | < 0.001b | 0.86 (0.80, 0.92) |
GH staining | 49 | 41(83.7) | 86 | 82(95.3) | 0.022c | 4.0 (1.1, 14.1) |
GH staining type | 25 | 39 | 0.11c | |||
• Rare | 14(56.0) | 14(35.9) | reference | |||
• Diffuse | 11(44.0) | 25(64.1) | 2.3 (0.81, 6.3) | |||
Pituitary hormone co-staining | 49 | 26(53.1) | 86 | 62(72.1) | 0.026c | 2.3 (1.10, 4.8) |
• TSH | 49 | 15(30.6) | 86 | 41(47.7) | 0.053c | 2.1 (0.98, 4.3) |
• Prolactin | 49 | 16(32.7) | 86 | 40(46.5) | 0.12c | 1.8 (0.86, 3.7) |
• ACTH | 49 | 2(4.1) | 86 | 10(11.6) | 0.14c | 3.1 (0.65, 14.7) |
• FSH | 49 | 0(0.0) | 86 | 4(4.7) | 0.30d | NA |
Granulation pattern | 8 | 15 | 0.13d | |||
• Densely | 4(50.0) | 13(86.7) | reference | |||
• Sparsely | 4(50.0) | 2(13.3) | 0.15 (0.02, 1.2) | |||
Cavernous sinus invasion | 46 | 31(67.4) | 85 | 28(32.9) | < 0.001c | 0.24 (0.11, 0.51) |
Optic chiasm compression | 47 | 25(53.2) | 84 | 17(20.2) | < 0.001c | 0.22 (0.10, 0.49) |