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Table 4 Labs and Tumor Properties of Patients with Complete Initial Resection

From: Acromegaly: a clinical perspective

Factor Incomplete
(N = 49)
Complete
(N = 86)
  
n n (%) or
Median [P25, P75]
n n (%) or
Median [P25, P75]
p-value Odds Ratios(95% CI)
Random GH level at Dx 46 25.4[4.5,62.9] 78 6.3[2.6,21.1] 0.001b 0.98 (0.97, 1.00)
IGF-1 level at Dx 49 784.0[675.0,1014.0] 84 752.0[528.5944.0] 0.30b 1.00 (1.00, 1.00)
2-h nadir post OGTT GH at Dx 12 8.2[1.8,29.7] 31 4.3[1.7,12.8] 0.59b 1.00 (0.99, 1.01)
Most recent random GH level 45 1.4[0.32,2.2] 82 0.59[0.30,1.6] 0.11b 0.99 (0.96, 1.02)
Most recent IGF-1 level 49 217.0[153.0,377.0] 84 205.5[161.0,272.5] 0.50b 1.00 (1.00, 1.00)
Most recent 2-h nadir post OGTT GH 9 0.51[0.21,1.3] 23 0.30[0.16,0.80] 0.35b 0.74 (0.26, 2.1)
Tumor size 49   85   0.077c  
 • Macroadenoma   44(89.8)   66(77.6)   reference
 • Microadenoma   5(10.2)   19(22.4)   2.5 (0.88, 7.3)
Tumor length/antero-posterior 43 22.0[14.0,29.0] 82 14.5[10.0,18.0] < 0.001b 0.92 (0.88, 0.96)
Tumor width/transverse 42 20.5[15.0,25.0] 74 14.5[10.0,18.0] < 0.001b 0.89 (0.84, 0.94)
Tumor height/craniocaudal 39 20.0[15.0,25.0] 66 13.0[9.0,16.0] < 0.001b 0.86 (0.80, 0.92)
GH staining 49 41(83.7) 86 82(95.3) 0.022c 4.0 (1.1, 14.1)
GH staining type 25   39   0.11c  
 • Rare   14(56.0)   14(35.9)   reference
 • Diffuse   11(44.0)   25(64.1)   2.3 (0.81, 6.3)
Pituitary hormone co-staining 49 26(53.1) 86 62(72.1) 0.026c 2.3 (1.10, 4.8)
 • TSH 49 15(30.6) 86 41(47.7) 0.053c 2.1 (0.98, 4.3)
 • Prolactin 49 16(32.7) 86 40(46.5) 0.12c 1.8 (0.86, 3.7)
 • ACTH 49 2(4.1) 86 10(11.6) 0.14c 3.1 (0.65, 14.7)
 • FSH 49 0(0.0) 86 4(4.7) 0.30d NA
Granulation pattern 8   15   0.13d  
 • Densely   4(50.0)   13(86.7)   reference
 • Sparsely   4(50.0)   2(13.3)   0.15 (0.02, 1.2)
Cavernous sinus invasion 46 31(67.4) 85 28(32.9) < 0.001c 0.24 (0.11, 0.51)
Optic chiasm compression 47 25(53.2) 84 17(20.2) < 0.001c 0.22 (0.10, 0.49)
  1. p-values: b = Kruskal-Wallis test, c = Pearson’s chi-square test, d = Fisher’s Exact test