Fig. 1

Signs and symptoms associated with excess GR antagonism, cortisol withdrawal, and adrenal insufficiency [8, 15, 16]. ^aThe presence of these signs and symptoms may not always be indicative of excess GR antagonism due to mifepristone and should also be considered in the context of the patient. ^bIncidence and magnitude may depend on concomitant medications being taken with mifepristone. ^cOccurs with primary adrenal insufficiency. Abbreviations: GR glucocorticoid receptor, MR mineralocorticoid receptor