Table 1 Basic characteristics at diagnosis of central precocious puberty of the gonadotropin releasing hormone (GnRH) analogue treated and untreated groups
Parameter | GnRHa treatment N = 27 | No treatment N = 24 | P value |
|---|---|---|---|
Age at diagnosis (years) | 7.3 ± 0.6 (5.7–8.0) | 7.6 ± 0.6 (6.0–8.0) | 0.101 |
Bone age at diagnosis (years) | 9.6 ± 1.7 (7.1–12.0) | 10.7 ± 1.7 (7.1–13.0) | 0.072 |
Advanced over chronological age (months) | 16.4 ± 11.8 (0–43.0) | 21.6 ± 12.0 (8.0–50.0) | 0.214 |
Weight at diagnosis (kg) | 32.9 ± 8.6 (22.0–58.0) | 36.4 ± 11.7 (17.0–67.0) | 0.250 |
Height at diagnosis (centimeters) | 130.6 ± 10.4 (114–149) | 135.6 ± 14.2 (98–162) | 0.189 |
BMI percentile at diagnosis | 80.5 ± 19.3 (15.2–98.9) | 75.7 ± 24.9 (1.0–98.4) | 0.480 |
Medical background | |||
Neurologic | 3 (11.1) | 5 (20.8) | 0.451 |
Developmental | 2 (8.3) | 4 (16.7) | 0.402 |
Fetal | 0.175 | ||
Small for gestational age | 1 (3.7) | 4 (16.7) | |
Large for gestational age | 1 (3.7) | 0 | |
Prematurity (< 37 weeks) | 4 (14.8) | 1 (4.2) | |
Endocrine | 0.661 | ||
Hypothyroidism | 1 (3.7) | 0 | |
NCCAH | 2 (7.4) | 2 (8.3) | |
Vitamin D deficiency | 0 | 2 (8.3) | |
Benign premature thelarche | 1 (3.7) | 1 (4.2) | |
Clinical presentation at diagnosis | 0.422 | ||
Pubarche and thelarche | 19 (70.4) | 12 (57.1) | |
Thelarche only | 5 (18.5) | 5 (23.8) | |
Pubarche only | 3 (11.1) | 4 (19.1) | |
LH at diagnosis (IU/L) | 1.9 ± 1.7 (0.1–6.2) | 2.1 ± 1.6 (0.3–6.0) | 0.722 |
FSH at diagnosis (IU/L) | 3.8 ± 2.3 (1.1–9.4) | 4.7 ± 1.9 (1.6–8.3) | 0.200 |
Estradiol at diagnosis (pmol/L) | 121.9 ± 56.4 (70–232) | 191.2 ± 246.6 (70–1080) | 0.296 |
LH/FSH ratio at diagnosis | 0.5 ± 0.3 (0.1–1.0) | 0.5 ± 0.4 (0.1–1.4) | 0.446 |