Table 2 Summary of pharmacokinetic parameters of BI 187004 after single oral dose administrations in healthy male volunteers

AUC_0-∞ [nmol*h/L]

–

(–)

2,500

(23.0)

5,910

(29.2)

12,400

(41.2)

25,900

(36.1)

51,100

(40.2)

111,000

(19.5)

109,000

(53.4)

191,000

(25.4)

AUC_0-24 [nmol*h/L]

212

(35.2)

1,490

(21.5)

4,380

(23.2)

9,450

(32.1)

19,900

(26.6)

43,100

(36.9)

82,100

(12.6)

71,700

(74.1)

135,000

(22.0)

C_max [nmol/L]

11.8

(75.0)

150

(19.7)

502

(14.0)

1,030

(14.4)

2,210

(27.8)

2,460

(56.2)

8,310

(11.0)

7,120

(64.9)

13,400

(34.1)

C₂₄ [nmol/L]

4.54

(25.2)

30.0

(28.0)

71.3

(46.1)

161

(66.3)

321

(50.8)

878

(36.0)

1,630

(25.9)

2,130

(22.5)

2,690

(36.0)

t_max [h]*

1.0

(1.0—1.5)

1.0

(1.0—1.5)

1.0

(0.5—2.5)

1.38

(0.5—1.5)

1.0

(0.5—3.0)

2.25

(1.0—2.5)

1.0

(0.5—2.0)

1.0

(1.0—24.0)

1.0

(0.5—1.0)

t_1/2 [h]

–

33.5

(14.4)

23.7

(18.0)

21.2

(17.8)

18.9

(19.7)

17.1

(35.6)

14.5

(8.92)

13.4

(28.9)

13.9

(16.0)

V_Z/F [L]

–

281

(27.7)

169

(44.3)

144

(52.2)

123

(49.8)

113

(53.3)

87.9

(14.6)

124

(48.2)

110

(16.1)

CL/F [L/h]

–

5.82

(23.0)

4.93

(29.2)

4.70

(41.2)

4.50

(36.1)

4.56

(40.2)

4.21

(19.5)

6.44

(53.4)

5.48

(25.4)

fe_0-72 h [%]

–

3.00

4.03

4.93

4.21

4.55

4.75

4.88

4.25