Fig. 2

Assessment of glucose metabolism based on OGTT (2A and B), IvGTT (2B) (n = 57) and CGM (2C) (n = 24). In panel 2A we show the individual trajectories of blood glucose measured using a 2-h OGTT test at visit 2. Based on glucose values at minute 120, we identified 7 subjects (labelled with red and orange subject labels) would be considered to have impaired glucose tolerance (orange labels) or to have clinical type 1 diabetes (red labels) according to the World Health Organization (see grey panel in 2A). In panel 2B we show a scatterplot and a regression line between the log2-transformed area under the curve (AUC) of OGTT glucose measurements versus the log2-transformed FPIR measurements from IvGTT at visit 1. The subjects labelled in orange and red correspond to those in panel 2A. In panel 2C we present the distributions of the glucose measurements obtained from the Continuous Glucose Monitor (CGM) over a 7-day period starting at visit 2. The subjects were sorted according to an increasing median glucose value. The individual glucose measurements are shown as points, with the boxplots showing the median and interquartile range, and the violin plot showing the distribution of the CGM glucose values for a given individual. The subjects shown in orange and red correspond to those in panels 2A and 2B