Heterogeneity of beta-cell function in subjects with multiple islet autoantibodies in the TEDDY family prevention study - TEFA

Table 2 Autoantibody status combinations detected for each subject up to visit 2 (n = 57)

IAA (n positive subjects = 28)	GADA (n positive subjects = 52)	IA-2A (n positive subjects = 38)	ZnT8W/Q/R (n positive subjects = 40)	Autoantibody count	n (%) subjects with a given autoantibody combination	Autoantibody combination group
+	+	+	+	4	12 (21.1)	A
–	+	+	+	3	10 (17.5)	B
–	+	–	+	2	10 (17.5)	C
+	+	+	–	3	4 (7.0)	D
+	+	–	+	3	3 (5.3)	D
+	+	–	–	2	6 (10.5)	D
+	–	+	+	3	3 (5.3)	D
–	+	+	–	2	7 (12.3)	D
–	–	+	+	2	2 (3.5)	D

The autoantibody combination group in the right-most column was defined based on the three most frequent autoantibody combinations, forming groups A-C (n = 12, 10, 10, respectively), with group D (n = 25) comprised of all remaining autoantibody combinations

ISSN: 2055-8260