Articles

A virtual teaching clinic for virtual care during the COVID-19 pandemic

The COVID-19 pandemic has prompted the rapid transition of in-person outpatient care to telemedicine, and clinical training to remote learning. The endocrinology fellows at the University of Michigan maintain ...

Authors: Xin He, Daniel Shelden, Andrew Kraftson, Tobias Else and Richard J. Auchus

Acromegaly and thyroid cancer: analysis of evolution in a series of patients

Acromegaly is associated with higher morbidity and mortality mainly due to cardiovascular disease. Data on the incidence and evolution of thyroid cancer in acromegaly are controversial. Our objective was to de...

Authors: Karina Danilowicz, Soledad Sosa, Mariana Soledad Gonzalez Pernas, Elizabeth Bamberger, Sabrina Mara Diez, Patricia Fainstein-Day, Alejandra Furioso, Mariela Glerean, Mirtha Guitelman, Débora Katz, Nicole Lemaitre, Alicia Lowenstein, Mariela del Valle Luna, María Paz Martínez, Karina Miragaya, Daniel Moncet…

Central pontine myelinolysis during treatment of hyperglycemic hyperosmolar syndrome: a case report

Central pontine myelinolysis (CPM) is a non-inflammatory demyelinating lesion of the pons. CPM and extrapontine demyelination (EPM) are together termed osmotic demyelination syndrome (ODS), a known and serious...

Authors: Koshi Kusumoto, Nobuyuki Koriyama, Nami Kojima, Maki Ikeda and Yoshihiko Nishio

Rapid response of Nelson’s syndrome to pasireotide in radiotherapy-naive patient

Nelson’s syndrome is a well-described complication following bilateral adrenalectomy for management of Cushing’s disease. There is no consensus on optimal management of Nelson’s syndrome, characterized by the ...

Authors: Xin He and Joanna L. Spencer-Segal

Evaluating the effectiveness of a multi-faceted inpatient diabetes management program among hospitalised patients with diabetes mellitus

Diabetes mellitus (DM) is one of the most common chronic diseases. Individuals with DM are more likely to be hospitalised and stay longer than those without DM. Inpatient hypoglycemia and hyperglycemia, which ...

Authors: Shih Ling Kao, Ying Chen, Yilin Ning, Maudrene Tan, Mark Salloway, Eric Yin Hao Khoo, E Shyong Tai and Chuen Seng Tan

The epidemiology, molecular pathogenesis, diagnosis, and treatment of maturity-onset diabetes of the young (MODY)

The most common type of monogenic diabetes is maturity-onset diabetes of the young (MODY), a clinically and genetically heterogeneous group of endocrine disorders that affect 1–5% of all patients with diabetes...

Authors: Ken Munene Nkonge, Dennis Karani Nkonge and Teresa Njeri Nkonge

Adrenal metastasis as the initial diagnosis of synchronous papillary and follicular thyroid cancer

Differentiated thyroid cancer uncommonly presents with distant metastases. Adrenal metastasis from differentiated thyroid cancer presenting as the initial finding is even less common.

Authors: Xin He, Scott A. Soleimanpour and Gregory A. Clines

Clinical management of patients with Cushing syndrome treated with mifepristone: consensus recommendations

While surgery is the first-line treatment for patients with endogenous hypercortisolism (Cushing syndrome [CS]), mifepristone has been shown to be a beneficial medical treatment option, as demonstrated in the ...

Authors: David R. Brown, Honey E. East, Bradley S. Eilerman, Murray B. Gordon, Elizabeth E. King, Laura A. Knecht, Brandon Salke, Susan L. Samson, Kevin C. J. Yuen and Hanford Yau

SHBG and total testosterone levels in men with adult onset hypogonadism: what are we overlooking?

Adult onset male hypogonadism (AOH) is a common clinical condition whose diagnosis and management are controversial, and is often characterized by a low level of SHBG, but our understanding of why testosterone...

Authors: Stephen J. Winters

Maturity-onset diabetes of the young type 5 a MULTISYSTEMIC disease: a CASE report of a novel mutation in the HNF1B gene and literature review

Diabetes mellitus with autosomal dominant inheritance, such as maturity-onset diabetes of the young (MODY), is a genetic form of diabetes mellitus. MODY is a type of monogenic diabetes mellitus in which multip...

Authors: Juan Camilo Mateus, Carolina Rivera, Miguel O’Meara, Alex Valenzuela and Fernando Lizcano

Acromegaly: a clinical perspective

To examine the clinical and hormonal profiles, comorbidities, treatment patterns, surgical pathology and clinical outcomes of patients diagnosed with acromegaly at the Cleveland Clinic over a 15-year period.

Authors: Lima Lawrence, Kenda Alkwatli, James Bena, Richard Prayson, Varun Kshettry, Pablo Recinos, Betul Hatipoglu, Kevin M. Pantalone, Robert Weil, Amir H. Hamrahian, Laurence Kennedy and Divya Yogi-Morren

Psychosocial distress, clinical variables and self-management activities associated with type 2 diabetes: a study in Ghana

Psychosocial distress can act as a barrier to diabetes self-care management and thus compromise diabetes control. Yet in Ghana, healthcare centres mainly focus on the medical aspect of diabetes to the neglect ...

Authors: Margaret Amankwah-Poku, Albert G. B. Amoah, Araba Sefa-Dedeh and Josephine Akpalu

Homozygous LMNA p.R582H pathogenic variant reveals increasing effect on the severity of fat loss in lipodystrophy

Classical heterozygous pathogenic variants of the lamin A/C (LMNA) gene cause autosomal dominant familial partial lipodystrophy type 2 (FPLD2). However, recent reports indicate phenotypic heterogeneity among carr...

Authors: Utku Erdem Soyaltin, Ilgin Yildirim Simsir, Baris Akinci, Canan Altay, Suleyman Cem Adiyaman, Kristen Lee, Huseyin Onay and Elif Arioglu Oral

A rare cause of atraumatic fractures: case series of four patients with tumor-induced osteomalacia

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome that presents with hypophosphatemia, bone pain, muscle weakness and fractures. We report a case series of four patients with TIO that resulted...

Authors: Debbie W. Chen, Gregory A. Clines, Michael T. Collins, Liselle Douyon and Palak U. Choksi

Improving the transitioning of pediatric patients with type 1 diabetes into adult care by initiating a dedicated single session transfer clinic

Young adults with type 1 diabetes face potential health problems and disruptions in accessing care related to their move from pediatrics into adult care. At a medium-sized pediatric hospital with no formal tra...

Authors: Sarah Williams, Leigh Anne Allwood Newhook, Heather Power, Rayzel Shulman, Sharon Smith and Roger Chafe

A study of glycemic variability in patients with type 2 diabetes mellitus with obstructive sleep apnea syndrome using a continuous glucose monitoring system

Obstructive sleep apnea syndrome (OSAS) in association with Type 2 Diabetes Mellitus (DM) may result in increased glycemic variability affecting the glycemic control and hence increasing the risk of complicati...

Authors: Suhas S. Khaire, Jugal V. Gada, Ketaki V. Utpat, Nikita Shah, Premlata K. Varthakavi and Nikhil M. Bhagwat

Nonalcoholic fatty liver disease and type 2 diabetes: where do Diabetologists stand?

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. The increasing prevalence of NAFLD mirrors that of obesity and type 2 diabetes over the last two decades.

Authors: Shaheen Tomah, Naim Alkhouri and Osama Hamdy

Making the equivocal unequivocal: standardization of clean margins in diabetic foot osteomyelitis

The prevalence of diabetes mellitus continues to rise. Diabetic foot ulcers with osteomyelitis are a diabetes-related complication presenting a significant burden to this cohort. A cure to diabetic foot osteom...

Authors: Brian M. Schmidt and Christine Jarocki

Unusual clinical features associated with congenital generalized lipodystrophy type 4 in a patient with a novel E211X CAVIN1 gene variant

Congenital generalized lipodystrophy (CGL) is a rare disorder characterized by the lack of adipose tissue and metabolic complications with predominantly autosomal recessive inheritance. There are 6 different g...

Authors: Ekaterina Sorkina, Polina Makarova, Liubov Bolotskaya, Irina Ulyanova, Tatyana Chernova and Anatoly Tiulpakov

A challenging case of Mesenchymal Chondrosarcoma involving the thyroid and special considerations for diagnosis

Thyroid ultrasound is usually used to risk-stratify incidental thyroid nodules. Nodules with high risk sonographic features for malignancy are evaluated by fine-needle aspiration. The role of core needle biops...

Authors: Noura Nachawi, Madelyn Lew, Kristine Konopka and Zahrae Sandouk

Impact of atherosclerotic cardiovascular disease on healthcare resource utilization and costs in patients with type 2 diabetes mellitus in a real-world setting

This study evaluated the impact of atherosclerotic cardiovascular disease (ASCVD) on healthcare resource utilization and costs in patients with type 2 diabetes mellitus (T2DM).

Authors: Wayne Weng, Ye Tian, Sheldon X. Kong, Rahul Ganguly, Malene Hersloev, Jason Brett and Todd Hobbs

Correction to: Atypical hyperglycemia presentation suggests considering a diagnostic of other types of diabetes: first reported GCK-MODY in Perú

It was highlighted that the original article [1] contained an error regarding the nomenclature in the gene described.

Authors: Juan Carlos Lizarzaburu-Robles, Juan Carlos Gomez-de-la-Torre, María del Carmen Castro-Mujica, Flor Vento, Sofia Villanes, Elizabeth Salsavilca and Chris Guerin

Atypical hyperglycemia presentation suggests considering a diagnostic of other types of diabetes: first reported GCK-MODY in Perú

Prevalence of maturity-onset diabetes of the young (MODY) is estimated between 1 and 2% of all diabetes cases. In Latin-America little information has been described about the frequency of the disease, perhaps...

Authors: Juan Carlos Lizarzaburu-Robles, Juan Carlos Gomez-de-la-Torre, María del Carmen Castro-Mujica, Flor Vento, Sofia Villanes, Elizabeth Salsavilca and Chris Guerin

Achieving postprandial glucose control with lixisenatide improves glycemic control in patients with type 2 diabetes on basal insulin: a post-hoc analysis of pooled data

To examine the impact on glycemic control of achieving postprandial glucose (PPG) target with lixisenatide, a once-daily glucagon-like peptide-1 receptor agonist approved in the US, in patients with uncontroll...

Authors: Jaime A. Davidson, William Stager, Sachin Paranjape, Rachele Berria and Lawrence A. Leiter

Isolated ACTH deficiency during single-agent pembrolizumab for squamous cell lung carcinoma: a case report

The programmed cell death 1 (PD-1) inhibitor pembrolizumab is a promising agent for treatment of several different malignancies, but as with all immunotherapy there is a potential risk of immune-related advers...

Authors: Sho Tanaka, Masaru Kushimoto, Tsukasa Nishizawa, Masahiro Takubo, Kazutaka Mitsuke, Jin Ikeda, Midori Fujishiro, Katsuhiko Ogawa, Ichiro Tsujino, Yutaka Suzuki and Masanori Abe

Vehicle ergonomics contributing to a diabetic foot ulcer

Diabetes mellitus continues to be a rising concern in the United States. It affects an estimated 9.4% of the population and approximately 1.5 million Americans are diagnosed annually. Approximately 85% of diab...

Authors: Christine Jarocki, Brian M. Schmidt and Crystal Murray Holmes

A case report of T-box 1 mutation causing phenotypic features of chromosome 22q11.2 deletion syndrome

The heterozygous microdeletion of chromosome 22q11.2 results in a spectrum of disorders, including DiGeorge syndrome (DGS) and velocardiofacial syndrome (VCFS), with phenotypic features that can include the cl...

Authors: Raad A. Haddad, Gregory A. Clines and Jennifer A. Wyckoff

Interpretation of common endocrine laboratory tests: technical pitfalls, their mechanisms and practical considerations

Pitfalls in hormonal assays are commonly seen in clinical practice and may lead to erroneous clinical impressions and treatments. In this article, we address common laboratory pitfalls encountered during evalu...

Authors: Raad A. Haddad, Donald Giacherio and Ariel L. Barkan

A quality improvement project to increase compliance with diabetes measures in an academic outpatient setting

American Diabetes Association (ADA) sets annual guidelines on preventative measures that aim to delay the onset of severe diabetes mellitus complications. Compared to private internal medicine clinics, residen...

Authors: Subhash Edupuganti, Jordan Bushman, Rhyan Maditz, Pradeep Kaminoulu and Alexandra Halalau

Endocrinology practice patterns of hypothyroidism and osteoporosis management in a U.S. tertiary academic medical center

The major published clinical guidelines for the management of hypothyroidism and osteoporosis are not uniformly consistent and may be a significant contributor to variability of clinical care delivered by endo...

Authors: Jien Shim, Tiffany Lin, Cody Dashiell-Earp, Meghan Nechrebecki and Angela M. Leung

Natural history of ROHHAD syndrome: development of severe insulin resistance and fatty liver disease over time

Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) is a rare syndrome with unknown etiology. Metabolic abnormalities are not known to be part of the syndro...

Authors: Abdel Wahab Jalal Eldin, Dilara Tombayoglu, Laura Butz, Alison Affinati, Rasimcan Meral, Mehmet Selman Ontan, Kelly Walkovich, Maria Westerhoff, Jeffrey W. Innis, Neehar D. Parikh and Elif A. Oral

A case of mistaken identity: classic Kaposi sarcoma misdiagnosed as a diabetic foot ulcer in an atypical patient

The presentation of Kaposi sarcoma is divided into four known clinical subtypes. In this case report we describe classic Kaposi sarcoma in an African-American heterosexual, diabetic, seronegative human immunod...

Authors: Garneisha M. Torrence and James S. Wrobel

Using insulin pump with a remote-control system in young patients with diabetes improves glycemic control and enhances patient satisfaction

Insulin delivery triggered by a remote control is an advanced feature offered by newer insulin pump systems. These remote-integrated pump systems might further improve glycemic control and patient satisfaction...

Authors: Asma Deeb, Mariette Akle, Layla Abdulrahman, Hana Suwaidi, Samar Awad and Sareea Remeithi

Identification of population characteristics through implementation of the Comprehensive Diabetic Retinopathy Program

Diabetic retinopathy is the most common cause of blindness in working-age adults. Characteristics of patients with diabetes presenting to a retina subspecialty clinic have not been adequately studied, limiting...

Authors: Nish Patel, Lilia Verchinina, Michele Wichorek, Thomas W. Gardner, Dorene Markel, Jennifer Wyckoff and Anjali R. Shah

Global epidemiology of prediabetes - present and future perspectives

Prediabetes is defined as an intermediate state of hyperglycaemia with glucose levels above the normal state but below the diagnostic levels of diabetes. It is increasingly recognised as an important metabolic...

Authors: Ulrike Hostalek

Diagnosis of acquired generalized lipodystrophy in a single patient with T-cell lymphoma and no exposure to Metreleptin

Metreleptin, a recombinant methionyl -human -leptin, was approved to treat patients with generalized lipodystrophy (GL) in February 2014. However, leptin therapy has been associated with the development of lym...

Authors: Nazanene H. Esfandiari, Melvyn Rubenfire, Adam H. Neidert, Rita Hench, Abdelwahab Jalal Eldin, Rasimcan Meral and Elif A. Oral

Transition from pediatric to adult care in emerging adults with type 1 diabetes: a blueprint for effective receivership

For adolescents and emerging adults, the transition from pediatrics to adult care is fraught with challenges both inside and outside the clinical arena, including assuming independent care for diabetes, workin...

Authors: Jennifer Iyengar, Inas H. Thomas and Scott A. Soleimanpour

Understanding the manifestation of diabetes in sub Saharan Africa to inform therapeutic approaches and preventive strategies: a narrative review

Globally, the burden of diabetes mellitus has increased to epidemic proportions. Estimates from the International Diabetes Federation predict that the greatest future increase in the prevalence of diabetes mel...

Authors: Davis Kibirige, William Lumu, Angus G. Jones, Liam Smeeth, Andrew T. Hattersley and Moffat J. Nyirenda

Spectrum of immune checkpoint inhibitors-induced endocrinopathies in cancer patients: a scoping review of case reports

Since 2011 six immune checkpoint inhibitors (ICI) have been approved to treat patients with many advanced solid tumor and hematological malignancies to improve their prognosis. Case reports of their endocrine ...

Authors: Meng H. Tan, Ravi Iyengar, Kara Mizokami-Stout, Sarah Yentz, Mark P. MacEachern, Li Yan Shen, Bruce Redman and Roma Gianchandani

Type 1 diabetes and hyperthyroidism in a family with celiac disease after exposure to gluten: a rare case report

Celiac disease (CD) is an autoimmune disorder related to the gluten and can be also associated with some other endocrine disorders such as type 1 diabetes and thyroid disease. Gluten exposure in CD may have es...

Authors: Azita Ganji and Meysam Moghbeli

Cushing’s syndrome with no clinical stigmata – a variant of glucocorticoid resistance syndrome

Cortisol resistance syndrome is a very rare condition characterized by high cortisol levels, but without any clinical features of Cushing’s syndrome. Our objective is to present such a case.

Authors: Ved V. Gossain, Mohammad El-Rifai, Preethi Krishnan and Bhavini Bhavsar

A new model for diabetes-focused capacity building – lessons from Sri Lanka

Sri Lanka is experiencing a rapid increase in the number of people with diabetes mellitus (DM) due to population growth and aging. Physician shortages, outdated technology, and insufficient health education ha...

Authors: Anjan K. Saha, Naresh Gunaratnam, Rashmi Patil, Monica Choo, Devika P. Bagchi, Ekta Jhaveri, Jennifer Wyckoff, Ganeika Bahu, Ulysses Balis, Paul Clyde and William H. Herman

Level of adherence to dietary recommendations and barriers among type 2 diabetic patients: a cross-sectional study in an Ethiopian hospital

Limited data are available regarding the level of adherence and barriers to dietary recommendations in individuals with type 2 diabetes in Africa including Ethiopia. Therefore, this study aimed at assessing th...

Authors: Asnakew Achaw Ayele, Yohannes Kelifa Emiru, Sofonyas Abebaw Tiruneh, Belete Achamyelew Ayele, Alemayehu Digssie Gebremariam and Henok Getachew Tegegn

Efficacy of radioactive iodine treatment of graves’ hyperthyroidism using a single calculated ¹³¹I dose

To evaluate the success rate of therapeutic administration of a single calculated ¹³¹I activity for eliminating hyperthyroidism due to Graves’ disease.

Authors: Ka Kit Wong, Barry L. Shulkin, Milton D. Gross and Anca M. Avram

How is neighborhood social disorganization associated with diabetes outcomes? A multilevel investigation of glycemic control and self-reported use of acute or emergency health care services

Diabetes management is influenced by a number of factors beyond the individual-level. This study examined how neighborhood social disorganization (i.e., neighborhoods characterized by high economic disadvantag...

Authors: Sarah D. Kowitt, Katrina E. Donahue, Edwin B. Fisher, Madeline Mitchell and Laura A. Young

Growth hormone: isoforms, clinical aspects and assays interference

The measurement of circulating concentrations of growth hormone (GH) is an indispensable tool in the diagnosis of both GH deficiency and GH excess. GH is a heterogeneous protein composed of several molecular i...

Authors: Júnia Ribeiro de Oliveira Longo Schweizer, Antônio Ribeiro-Oliveira Jr and Martin Bidlingmaier

The journey continues in Clinical Diabetes and Endocrinology

Authors: Ariel Barkan, Roma Gianchandani and Meng H. Tan

Current treatment strategies for patients with advanced gastroenteropancreatic neuroendocrine tumors (GEP-NETs)

Neuroendocrine tumors (NETs) are rare neoplasms, with an estimated annual incidence of ~ 6.9/100,000. NETs arise throughout the body from cells of the diffuse endocrine system. More than half originate from en...

Authors: Inbal Uri and Simona Grozinsky-Glasberg

Pheochromocytoma and Paraganglioma in Neurofibromatosis type 1: frequent surgeries and cardiovascular crises indicate the need for screening

Pheochromocytomas and Paragangliomas (PCC/PGL) are rare endocrine tumors that are mostly benign, but often hormone producing, causing significant morbidity and mortality due to excess catecholamine secretion a...

Authors: Elisabeth Joye Petr and Tobias Else

Weight loss and bone mineral density in obese adults: a longitudinal analysis of the influence of very low energy diets

The long-term effect of weight reduction on skeletal health is not well understood. The purpose of this study was to examine the impact of an intensive medical weight loss intervention using very low energy di...

Authors: Palak Choksi, Amy Rothberg, Andrew Kraftson, Nicole Miller, Katherine Zurales, Charles Burant, Catherine Van Poznak and Mark Peterson