Fig. 6
From: Hyperglucagonemia in an animal model of insulin- deficient diabetes: what therapy can improve it?
Effect of leptin treatment in Akita mice. a Five mice had implanted the osmotic pump containing leptin; 13 mice were sham-operated. At 9 days after initiating treatment, blood glucose was significantly lower in leptin-treated animals, *: p < 0.05; at 22 days of age p = 0.06; at 27 days of age p = 0.07. b Glucagon secretion is blunted during leptin treatment, *p: < 0.0009. Plasma glucagon was measured 12 days after the osmotic pump containing leptin was implanted. c No differences in food intake were found between leptin-treated (5) or sham- operated (13) Akita mice. d OGTT in leptin-treated (5) and sham-operated (10) Akita mice. *: p < 0.05