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Table 2 TAO Eye changes classification - NOSPECS

From: Update on thyroid-associated Ophthalmopathy with a special emphasis on the ocular surface

NOSPECS

Class

Grade

Criteria

1

 

No physical signs or symptoms

 

Only signs (limited to upper lid retraction, stare, and lid lag)

2

 

Soft tissue involvement (with symptoms and signs)

0

Absent

a

Minimal

b

Moderate

c

Marked

3

 

Proptosis ≥3 mm above upper normal limit

0

Absent

a

3–4 mm increase over upper normal

b

5–7 mm increase

c

≥8 mm increase

4

 

Extraocular muscle involvement

0

Absent

a

Limitation of motion extremes of gaze

b

Evident restriction of motion

c

Fixation of a globe or globes

5

 

Corneal involvement

0

Absent

a

Stippling of cornea

b

Ulceration

c

Clouding, necrosis, perforation

6

 

Sight loss (optic nerve involvement)

0

Absent

a

Disc pallor or visual field deffect; vision 20/20–20/60

b

Same as 6a, but vision 20/70–20/200

c

Blindness, i.e., failure to perceive light, vision < 20/200