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Table 3 Prediction of insulin glargine 100 Units/mL response at 24 weeks based on early response at 12 weeks

From: Characteristics of insulin-Naïve people with type 2 diabetes who successfully respond to insulin glargine U100 after 24 weeks of treatment: a meta-analysis of individual participant data from 3 randomized clinical trials

   Responders at week 24
Yes No
Responders at Week 12 Yes 91% 9%
No 46% 54%
Predictive parameters
 Odds ratio = 12.7 (P < 0.001)
 Sensitivity = 85.9%
 Specificity = 67.7%
 Positive predictive value = 91.4%
 Negative predictive value = 54.5%
  1. Sensitivity is the percentage of subsequent responders (HbA1c <7% or ≥ 1% reduction) correctly identified (true-positive rate). Specificity is the percentage of subsequent nonresponders (HbA1c ≥7% and < 1% reduction) correctly identified (true-negative rate). Positive predictive value is the percentage of subsequent responders among early responders. Negative predictive value is the percentage of subsequent nonresponders among early nonresponders. Abbreviation: HbA1c glycated hemoglobin