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Table 3 Prediction of insulin glargine 100 Units/mL response at 24 weeks based on early response at 12 weeks

From: Characteristics of insulin-Naïve people with type 2 diabetes who successfully respond to insulin glargine U100 after 24 weeks of treatment: a meta-analysis of individual participant data from 3 randomized clinical trials

  

Responders at week 24

Yes

No

Responders at Week 12

Yes

91%

9%

No

46%

54%

Predictive parameters

 Odds ratio = 12.7 (P < 0.001)

 Sensitivity = 85.9%

 Specificity = 67.7%

 Positive predictive value = 91.4%

 Negative predictive value = 54.5%

  1. Sensitivity is the percentage of subsequent responders (HbA1c <7% or ≥ 1% reduction) correctly identified (true-positive rate). Specificity is the percentage of subsequent nonresponders (HbA1c ≥7% and < 1% reduction) correctly identified (true-negative rate). Positive predictive value is the percentage of subsequent responders among early responders. Negative predictive value is the percentage of subsequent nonresponders among early nonresponders. Abbreviation: HbA1c glycated hemoglobin
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Clinical Diabetes and Endocrinology

ISSN: 2055-8260

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