Table 1 Hormones of the HPA axis: mean difference from baseline
Parameter [Reference Range]/Time point/Difference from baseline | Placebo N = 17 | 2.5 mg N = 6 | 5 mg N = 6 | 10 mg N = 6 | 20 mg N = 6 | 40 mg N = 6 | 80 mg N = 6 | 160 mg N = 6 | 240 mg N = 6 | 360 mg N = 6 |
|---|---|---|---|---|---|---|---|---|---|---|
Cortisol [171 – 536 nmol/L] | ||||||||||
Baseline | 396.1 | 359.7 | 338.1 | 395.6 | 330.8 | 301.3 | 325.7 | 258.1 | 219.4 | 347.8 |
24:00 | -39.0 | -77.1 | 1.8 | -78.7 | 18.4 | -48.8 | 102.6 | -49.2 | -7.3 | -40.0 |
96:00 | -46.6 | -65.3 | -75.0 | -128.8 | -34.1 | -75.5 | -64.4 | -69.9 | -5.1 | -132.9 |
ACTH [1.03 – 10.74 pmol/L] | ||||||||||
Baseline | 4.96 | 3.80 | 4.26 | 4.59 | 3.25 | 2.52 | 2.01 | 2.82 | 3.64 | 3.42 |
24:00 | -1.22 | 0.59 | 0.53 | 0.78 | 1.53 | 1.44 | 4.69 | 1.34 | 0.87 | 1.30 |
96:00 | -1.84 | -0.46 | -1.65 | -1.35 | -0.58 | -0.01 | 1.36 | 0.05 | -0.27 | 0.38 |
DHEA-s [2.6 – 13.0 μmol/L] | ||||||||||
Baseline | 6.4 | 5.2 | 5.0 | 5.1 | 5.8 | 5.7 | 6.0 | 4.1 | 5.2 | 4.3 |
24:00 | 0.0 | 0.7 | 1.6 | 1.2 | 2.2 | 1.7 | 2.6 | 1.6 | 1.6 | 1.2 |
96:00 | 1.1 | 2.1 | 0.9 | 1.9 | 2.1 | 2.3 | 2.4 | 2.2 | 2.3 | 1.6 |
Androstenedione [1.1 – 10.9 nmol/L] | ||||||||||
Baseline | 9.6 | 11.0 | 10.5 | 8.1 | 5.9 | 8.4 | 9.8 | 6.2 | 7.5 | 6.7 |
24:00 | -2.3 | 0.2 | 1.2 | 1.3 | 3.7 | 3.7 | 8.1 | 2.6 | 5.0 | 3.2 |
96:00 | -2.6 | -1.8 | -3.7 | -3.4 | 3.8 | 0.1 | 0.5 | 1.5 | 2.7 | -0.3 |
Total Testosterone [9.9 – 27.9 nmol/L] | ||||||||||
Baseline | 16.1 | 18.4 | 16.7 | 18.7 | 15.4 | 20.3 | 16.3 | 13.4 | 15.6 | 11.6 |
24:00 | 0.2 | 0.1 | -0.9 | -0.2 | -1.3 | -0.5 | 0.8 | 1.0 | -2.8 | -0.3 |
96:00 | -0.3 | -0.3 | -0.7 | -2.0 | -1.0 | -0.8 | 0.6 | 2.4 | -2.4 | 0.7 |
SHBG [10 – 80 nmol/L] | ||||||||||
Baseline | 25.7 | 32.1 | 28.2 | 33.7 | 28.4 | 37.6 | 29.1 | 29.5 | 27.2 | 28.5 |
24:00 | 1.8 | 2.6 | 3.0 | 3.4 | 2.9 | 0.6 | 2.1 | 1.9 | 2.3 | 0.9 |
96:00 | 0.6 | -0.1 | 2.7 | 0.2 | 1.3 | -1.8 | -1.3 | -0.8 | 2.5 | -2.2 |