Hyperinsulinemic hypoglycemia in adolescents: case report and systematic review

Table 2 Systematic review of the existing reports of nesidioblastosis in teenagers or adults

	Year	Nr of pts / Nr adoles.	Age	Sex	Medical treatment	Surgical treatment	Type of surgery	Resolved	Follow-up/survival
Dahms B et al. [11]	1980	16/1	15	M	-	+	SDP (2 procedures)	YES	5 years
Harness JK et al. [12]	1981	6/2	11 20	F M	+	+	SDP	YES	6 years 3 months
Dunger DB et al. [13]	1988	10/2	10 11	DNR	+	+	SDP	YES	NA
Pedrazzoli S et al. [14]	1994	58/1	16	M	-	+	DP	YES	4 years
Rother KL et al. [15]	1995	12/1	12	M	+	+	SDP	YES	NA
Leibowitz G et al. [16]	1995	14/11	11 to 24	8F	+ (11)	+ (8)	DP	YES	NA
Fuller PJ et al. [17]	1997	1	24	F	+	+	SDP	YES	2.5 years
Dacou-Voutatakis C et al. [18]	1998	15/5	10 to 20	DNR	+	+ (1)	SDP	YES	NA
Ueda Y et al. [19]	1998	1	23	M	-	+	DP	YES	2 years
Van der Wall B et al. [20]	1999	2/1	16	F	+	+	DP	YES	5 years
Service FJ et al. [21]	1999	5/1	16	M	-	+	SDP	YES	3 years
Thompson G et al. [22]	2000	10/1	16	M	-	+	SDP	YES	4 years
Witeless RM et al. [23]	2001	1	22	M	-	+	SDP	YES	21 years
Martinez Ibannez V et al. [24]	2002	29/2	10 12	DNR	+	1	SDP	YES	NA
Bin-Abbas BS et al. [25]	2004	1	14	F	+	-	-	Diabetes	8 years
Anlauf M et al. [26]	2005	15/3	18 20 21	F M M	+	+	SDP	2 YES	14 years
Raffel A et al. [27]	2007	4/1	18	M	+	+	SDP	YES	11.5 years
Kovacs E et al. [28]	2008	1	22	M	+	-	-	YES	NA
Restrepo K et al. [29]	2009	1	20	F	+	+	DP	YES	8 weeks ^a
Soares F et al. [30]	2013	1	22	F	-	+	TP	YES	NA
De Jesus et al. [31]	2015	1	14	F	+	+	SDP	YES	2 years
Castillo-Lopez et al. [32]	2020	1	15	M	+	+	DP	YES	1 year
Summary	1989 - 2020	205/41	10 to 24 years	-	34	32	23 SDP	39 yes	3 months to 21 years

TP Total Pancreatectomy, SDP Subtotal - Distal Pancreatectomy, DP Distal Pancreatectomy, DNR Does not report, P Pancreatectomy, CDP cephalic duodenopancreatectomy.
(^* 8 weeks after patient requires to have a TP to be completed, and the pathologist reports the existence of a 1.5 cm nodule positive for insulinoma with a 1% positive Ki-67).

ISSN: 2055-8260